Neuro Endocrine Tumor

  Mohammad Afkhami-Ardekani MD

Professor of Endocrinology and Metabolism

Shad Sadoughi University of Medical Siences

14 NOV 2018

Neuroendocrine Tumors (NETs)

Case  report 1:

A 47-year-old man, with a past medical history significant for seizure disorder. He denied any epigastric discomfort, weight loss, dysphasia, nausea, emesis, constipation, or diarrhea.

Organomegaly was appreciated with the liver edge to be estimated 8-10 cm below the costal margin.

Ultrasound revealed hepatomegaly with diffusely inhomogeneous echotexture and splenomegaly.

The appearance of the liver was suggestive of extensive metastatic disease. 

There was also a large mass extending towards the tail of the pancreas.

A core needle biopsy of the liver was obtained,  Mild nuclear pleomorphism was present. 

The results showed positivity for chromograninA

A diagnosis of Neuroendocrine carcinoma  was made at this time.

Case report 2:

A 70-year-old man complained of left flank pain.

Abdominal computed tomography (CT) revealed  a 6.8-cm lobulated solid mass in the liver dome.

 He did not have any other symptoms such as jaundice, vomiting, flushing, or diarrhea before admission.

 Liver magnetic resonance imaging (MRI) revealed a lobulated mass with mild hypervascularity.

The resected specimen revealed a solid tumor measuring 8.3 cm × 6.5 cm.

The result show postive for Chromogranin A.

A diagnosis of Neuroendocrine carcinoma  was made at this time.